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Research 1890; Clinical Cases 1386 Mar 21, 2023 · This article was published on March 21, 2023, and last updated on May 25, 2023, at NEJM. Disclosure Forms (nejmra1616601_disclosures. 0 in women), and May 15, 2024 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. 4 days ago · Test your diagnostic and therapeutic skills at NEJM. 3%) had a severity level In response, the New England Journal of Medicine has become a journal signatory to the following statement. 389 No. New England Journal of Medicine. org Mar 27, 2023 · A data sharing statement provided by the authors is available with the full text of this article at NEJM. Research Summary (nejmoa2310234_research-summary. pdf) Jun 12, 2024 · Explore Cardiology articles from The New England Journal of Medicine. All Jun 4, 2023 · This article was published on June 4, 2023, at NEJM. They studied 800,000 adults from a larger community Sep 28, 2021 · The solution for this serious threat to ED staff and harm to patients cannot come from a single department, but through engagement of and ongoing commitment by leaders throughout the hospital and, more broadly, by those in the payer and regulatory segments of the health care system as well. Disclosure forms provided by the authors are available with the full text of this article at NEJM. 5 bring greater clarity to how SARS-CoV-2 infection may affect cognition. Editor. The primary outcome occurred in 490 of 4687 patients (10. 0%) underwent screening, and 56,365 in the usual-care group. Aug 25, 2021 · A complete definition of the study variables is included in Table S1 in the Supplementary Appendix, available with the full text of this article at NEJM. Study Design and Oversight In this article in the series on artificial intelligence in medicine, the authors explore how human values influence the outputs of large language models and other artificial intelligence models Jan 17, 2024 · NEJM Catalyst offers a free collection of articles and interviews with global health care leaders rising to meet the challenge of the Covid-19 pandemic. The multinational outbreak of mpox (formerly known as monkeypox) that began in 2022 resulted in more than 90,000 reported cases, over 150 deaths, and — importantly — a coordinated international response to a rapidly spreading infectious disease. Supported by Pfizer . SPECIALTIES. A data sharing statement provided by the authors is available with the full text of this article at NEJM. Jan 27, 2021 · Atrial fibrillation is associated with an increased incidence of stroke (by a factor of approximately 4. 7 in women), heart failure (by a factor of 3. 2024. 5 It is more common in persons Aug 7, 2024 · Explore Endocrinology articles from The New England Journal of Medicine. Jan 11, 2023 · In a random sample of 2809 admissions, we identified at least one adverse event in 23. Mar 29, 2023 · A chatbot consists of two main components: a general-purpose AI system and a chat interface. pdf) Nov 5, 2021 · This article was published on November 5, 2021, and last updated on December 30, 2021, at NEJM. Research Summary (nejmoa2304146_research-summary. 5% of deaths per year worldwide. 6% of all visits to emergency departments and is a frequent reason for hospitalizations in the United States. In phase 1 trials, JNJ-75220795, a hepatocyte-targeted GalNAc-conjugated PNPLA3 siRNA, reduced liver fat in PNPLA3 The New England Journal of Medicine (NEJM) offers multiple access levels to content and features at NEJM. A 70-year-old man with rheumatoid arthritis presented with painful, red lesions on the right side of his penis and scrotum and on his inner right thigh and a 1-day history of difficulty urinating. December 2019. Figure 1 Mechanical Aug 28, 2021 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. Patel, Andrew P. Jun 13, 2024 · A 59-year-old woman was referred for evaluation of a breast lesion of 27 years’ duration. Risk factors are known for populations, and psychological models address individual risks; the models and tools for assessing s. 22). Aug 8, 2024 · Explore Rheumatology articles from The New England Journal of Medicine. While often dismissed as mere inconvenience for patients, impact of ED crowding on avoidable patient morbidity Apr 5, 2023 · This article was published on April 5, 2023, at NEJM. 391 NO. S. On examination, a large, fungating mass with bleeding was present in the right breast. Research 3802; Clinical Cases 2002; Other 1616 In participants with advanced renal-cell carcinoma, belzutifan, a HIF-2α inhibitor, was superior to everolimus, an mTOR inhibitor, with respect to progression-free survival and tumor response. If a trial was ongoing or started after September 13, 2005, it MUST have been registered in one of the four functional WHO/ICMJE-compatible databases as of December 31 Mar 29, 2023 · The protocol (available with the full text of this article at NEJM. Aug 31, 2022 · This article was published on August 31, 2022, at NEJM. In that report, the authors conducted a meta-analysis to estimate the pooled odd ratios for a number of health effects associated with the use Feb 25, 2024 · This article was published on February 25, 2024, and updated on February 28, 2024, at NEJM. Read Full Statement. Fuse Brown DOI:10. Supported by Bayer . The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of Jan 16, 2020 · Suicide accounts for approximately 1. Supported by Sanofi and Oct 26, 2022 · This article was published on October 26, 2022, at NEJM. Jun 12, 2024 · Explore Surgery articles from The New England Journal of Medicine. Volume 384 • Number 8 • February 25, 2021. Supported by AstraZeneca . Paper reprints are high-quality reproductions of NEJM articles — available in quantities ranging from as few as 100 to 500,000 or more — that can be distributed anywhere in the world. Jun 13, 2024 · Explore Hematology/Oncology articles from The New England Journal of Medicine. org). Jun 26, 2024. pdf) Aug 24, 2022 · During the study period, the omicron variant was the dominant strain in Israel (see Fig. A data sharing statement provided by the authors is available with the full text of this article at Jan 10, 2022 · The Editors announce the launch of NEJM Evidence, a monthly, peer-reviewed, online-only general medical journal publishing original research as well as articles focused on understanding trial desig Nov 7, 2019 · Acute severe hypertension accounts for an estimated 4. A data sharing statement provided by the authors is available with the full text of this article at Explore the various article metrics used by The New England Journal of Medicine to measure the impact and reach of their publications. Supported by BioNTech Jan 3, 2024 · A challenge of therapeutics in Alzheimer’s disease has been restriction by the blood–brain barrier of the delivery of therapeutic agents to brain tissue. In August, the U. Jun 26, 2023 · This article was published on June 26, 2023, at NEJM. We thank the participants who enrolled in the trial and the staff at the trial sites; the Mar 22, 2023 · A detailed discussion of the pathophysiology of right ventricular failure is provided in the Supplementary Appendix, available with the full text of this article at NEJM. Supported by Madrigal Dec 15, 2021 · Disclosure forms provided by the author are available with the full text of this article at NEJM. R. pdf) Audio summary from the New England Journal of Medicine — NEJM This Week — August 22, 2024. Research 1752; Review 760; Commentary Explore the current issue of The New England Journal of Medicine (Vol. Supported by a grant (2018YFA0800404) Oct 24, 2023 · The trial design, details regarding oversight, and results at 1 and 2 years have been published previously. A data sharing statement provided by the authors is available with the full text of this article at Oct 23, 2020 · This article was published on October 23, 2020, at NEJM. A 62-year-old, right-handed, independently functioning man presents 1 hour after a sudden, witnessed onset of speech difficulty and Nov 4, 2020 · Migraine is the second most prevalent neurologic disorder (after tension-type headache), with a female-to-male ratio of 3:1 and an estimated 1-year prevalence of approximately 15% in the general Dec 16, 2020 · New England Journal of Medicine. 5%) in the naltrexone–bupropion group and 10 of 294 (3. Research; Reviews; Clinical Cases; Perspective; Commentary; Other Dec 21, 2017 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. Dec 10, 2020 · This article was published on December 10, 2020, and updated on December 16, 2020, at NEJM. Jul 6, 2022 · Pulmonary embolism occurs when embolic venous thrombi are caught within the branching lung vasculature. In the first stage, 18 of 109 participants (16. Disclosure Forms (nejmra2034954_disclosures. Save. Supported by Novo Nordisk . Among 978 adverse events, 222 (22. 13,15 The trial protocol (available with the full text of this article at NEJM. 4%) in the placebo Jun 25, 2024 · Explore Review Article articles from NEJM Evidence. 1 years). A data sharing statement provided by the authors is available with the full text of this article at The New England Journal of Medicine (NEJM) Images in Clinical Medicine article type captures and illuminates the sense of visual discovery and variety that physicians experience every day in The journal's logo depicts the snake-wrapped Rod of Asclepius crossed over a quill pen. Aug 27, 2021 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. Study Population Mar 20, 2019 · Helicobacter pylori infection is a common, usually lifelong, infection that is found worldwide. C. 3; Jul 18, 2024; Necrotizing Soft-Tissue and Retropharyngeal Space Infections and Mediastinitis. Feb 27, 2024 · Abstract. Nov 12, 2023 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. 4%), with Jan 1, 2020 · Head and neck cancer was the seventh most common cancer worldwide in 2018 (890,000 new cases and 450,000 deaths), 1 accounting for 3% of all cancers (51,540 new cases) and just over 1. 1 Evidence from case series and expert opinion suggests that liver disease, alcohol use, hypokalemia, severe hyponatremia, and malnutrition increase the risk of ODS. Research Summary (nejmoa2204737_research-summary. pdf) Feb 28, 2024 · In a study published in this issue of the Journal, Hampshire et al. Dec 11, 2020 · This article was published on December 11, 2020, and updated on January 5, 2021, at NEJM. Original Article. 1,2 Among U. Volume 342 • Number 21 • May 25, 2000 Dec 7, 2022 · This article was updated on December 7, 2022, at NEJM. Apr 20, 2022 · A data sharing statement provided by the authors is available with the full text of this article at NEJM. pdf) In this article in the series on artificial intelligence in medicine, the authors explore how human values influence the outputs of large language models and other artificial intelligence models NEJM seeks submissions of original research, reviews, case reports, and commentaries that improve patient care and clinical practice, or that offer new information about the biology of disease. Supplementary Material Plain Language Summary (nejmoa2313040_plain-language-summary. All Feb 7, 2024 · This article was last updated on February 16, 2024, at NEJM. The NEJM policy is firm. Disclosure forms provided by the author are available with the full text of this article at NEJM. Aug 28, 2021 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. 2 Overly rapid correction of serum sodium is also associated with Feb 10, 2021 · This article was published on February 10, 2021, at NEJM. Dear Reader, and steadily increased. The dates on the logo represent the founding of the components of The New England Journal of Medicine: 1812 for the New England Journal of Medicine and Surgery and Collateral Branches of Medical Science, 1823 for the Boston Medical Intelligencer, 1828 for the Boston Medical and Surgical Journal, and 1928 Sep 24, 2020 · This article was published on September 24, 2020, at NEJM. 73 m 2 of body-surface area, or who had Mar 29, 2023 · This first article in a series describes the history of artificial intelligence in medicine; the use of AI in image analysis, identification of disease outbreaks, and diagnosis; and the use of chat Jul 21, 2022 · This article was published on July 21, 2022, and updated on August 25, 2022, at NEJM. Advanced Search SEARCH. The authors vouch for the accuracy and completeness of Jul 31, 2024 · Supreme Power — The Loss of Judicial Deference to Health Agencies. 0 in men and 5. Research 830; Clinical Cases 530; Media 420 May 21, 2023 · This article was published on May 21, 2023, at NEJM. Explore the index of articles published by the New England Journal of Medicine, from original research to videos in clinical medicine and more. Jan 13, 2021 · A total of 403 participants were enrolled in stage 1, and 225 in stage 2. 1 Because of decades of global preparedness efforts, vaccines and therapeutics for a May 25, 2022 · The relationship between type 2 diabetes and both coronary artery disease and renal disease is well established. 1 It is one of the most common chronic, noncommunicable diseases in the country and worldwide. pdf) Download; Feb 15, 2023 · The relevant independent ethics committees or institutional review boards for each trial site approved the protocol and amendments (available with the full text of this article at NEJM. Jun 16, 2023 · The design of the CONVINCE trial has been published previously, 11,12 as described in the trial protocol, which is available with the full text of this article at NEJM. pdf) Oct 30, 2019 · Schizophrenia is a psychiatric syndrome characterized by psychotic symptoms of hallucinations, delusions, and disorganized speech, by negative symptoms such as decreased motivation and diminished Aug 19, 2010 · Of the 151 patients who underwent randomization, 27 died by 12 weeks and 107 (86% of the remaining patients) completed assessments. By Article Category. An Editorial Reflection of Articles in This Special Issue of IJERPH, Jan 7, 2021 · Index of all Issues from New England Journal of Medicine Sep 24, 2020 · This article was published on September 24, 2020, at NEJM. E. Sep 8, 2021 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. 7%) were judged to be preventable and 316 (32. org. I thank Carol Farver, University of Michigan, and Jody Hooper, Johns Hopkins University, for Feb 17, 2022 · This article was published on February 17, 2022, at NEJM. 13 The first completed large clinical outcome trial of an SGLT2 inhibitor in Oct 13, 2021 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. Pulton, Regina E. Dec 25, 2019 · This article was last updated on February 12, 2020, at NEJM. Feb 16, 2022 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. Pages: 768-773. The current situation requires navigating complex social, economic, political, and clinical terrain. Skip to main content. Images in Clinical Medicine; VOL. Sep 28, 2022 · The trial protocol, which is available with the full text of this article at NEJM. S1 in the Supplementary Appendix, available with the full text of this article at NEJM. May 25, 2000 · In this article, we focus on the treatment of hyponatremia, emphasizing a quantitative approach to its correction. Supported by grants (U10CA180868 and U10CA180822) from the National Cancer Institute Nov 11, 2023 · The trial rationale and design have been reported previously. Apr 3, 2024 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. Supported by Bayer and Jul 23, 2023 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. 5%) in the pooled empagliflozin group and in 282 of 2333 This episode from the New England Journal of Medicine's "Intention to Treat" podcast looks at two tools — a key measure of kidney function and a risk calculator for vaginal birth after cesarean delivery — that have long contributed to health and health care inequities for Black patients. Jul 17, 2024 · Explore a collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary. Written informed consent was obtained from all adult Sep 8, 2023 · The prevalence of asthma in adults in the United States is approximately 7. org) was approved by the institutional review board or Apr 5, 2023 · This article was published on April 5, 2023, at NEJM. Jul 21, 2021 · Details of this analysis are described in Section S1 in the Supplementary Appendix, available with the full text of this article at NEJM. Research Summary (nejmoa2107038_research-summary. 1056/EVIDoa2300229) by Glantz et al. 1 Low-intensity focused ultrasound Jul 31, 2024 · Homozygosity for the PNPLA3 risk allele is linked to liver fat accumulation. adults A collection of articles selected by NEJM editors. 1 Studies suggest that infection rates vary according to geographic region, but the number of 4 days ago · A 29-year-old woman with a history of systemic lupus erythematosus presented to the dermatology clinic with a 2-week history of a rash on her nose and hands that had appeared 1 day after the Apr 5, 2023 · The authors vouch for the completeness and accuracy of the reported data and for the fidelity of the study to the protocol, which is available with the full text of this article at NEJM. Disclosure Forms (nejmra2027424_disclosures. Jul 15, 2020 · The article ends with the author’s clinical recommendations. Research Summary (nejmoa2110956_research-summary. org) was Nov 26, 2015 · A total of 7020 patients were treated (median observation time, 3. The United Nations High Commissioner for Refugees reports that more than 100 million people have been forcibly displaced from their homes due to persecution, conflict, violence, and human rights violations. 6%. pdf) Download; Oct 19, 2022 · This article was updated on October 27, 2022, at NEJM. org) was designed by the sponsor (LimFlow) with input from the principal investigators and approved by the Food and Drug Jun 13, 2024 · Explore Pulmonary/Critical Care articles from The New England Journal of Medicine. org including:. Jun 25, 2021 · This article was published on June 25, 2021, and updated on July 15, 2021, at NEJM. Feb 16, 2022 · This article was published on February 16, 2022, at NEJM. 7±6. Supplementary Material. Original Article; Aug 05, 2020; Zika Virus Disease in Colombia. Mar 29, 2023 · The editors announce both a series of articles focusing on AI and machine learning in health care and the 2024 launch of a new journal, NEJM AI, a forum for evidence, resource sharing, and discussi Jul 26, 2023 · The authors, both employed by a company providing consulting services for public and private health care organizations, examine the use of AI in reimbursement, clinical operations, and quality and Jul 25, 2023 · In volume 3, number 3 of NEJM Evidence, we published an article entitled “Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes” (DOI: 10. Sachs and E. The trial aimed to Oct 9, 2022 · Follow-up data were available for 84,585 participants in Poland, Norway, and Sweden — 28,220 in the invited group, 11,843 of whom (42. Patients assigned to early palliative care had a better quality Mar 23, 2023 · Osmotic demyelination syndrome (ODS) is a rare but potentially devastating complication of hyponatremia that can lead to temporary or permanent neurologic injury. LOOKING FOR SPECIALTIES? VIEW SPECIALTIES. This article considers specifically an AI system called GPT-4 (Generative Pretrained Transformer 4 Jan 10, 2024 · Peripartum cardiomyopathy is now a leading cause of maternal death in many parts of the United States and around the world. 12-14 Approximately 60% of cases of cardiogenic shock during pregnancy Jan 28, 2023 · SARS-CoV-2 will continue to play a major role in our lives for the foreseeable future. Apr 10, 2024 · To help approach these knowledge gaps, the Journal announces the launch, in this issue, of a new review article series centered on fundamental and emerging concepts in nutrition, ranging from the Oct 5, 2020 · This article was published on October 5, 2020, at NEJM. 391 No. A data sharing statement provided by the authors is available with the full text of this article at Sep 28, 2021 · Emergency department crowding is a sentinel indicator of health system functioning. 9 The trial protocol (available with the full text of this article at NEJM. Notarianni, Archer Kilbourne Martin, Albert Tsai, Danielle A. pdf) Download; Nov 29, 2022 · This article was published on November 29, 2022, at NEJM. Supported by Janssen Research Jun 4, 2022 · This article was published on June 4, 2022, and updated on July 21, 2022, at NEJM. Clinical Cases 484; Research 407; Review 220; Media Explore this issue of The New England Journal of Medicine (Vol. 8). These thrombi often develop within the leg or pelvic veins, and approximately half of all In this article in the series on artificial intelligence in medicine, the authors explore how human values influence the outputs of large language models and other artificial intelligence models Mar 11, 2023 · This article was published on March 11, 2023, at NEJM. Polyethylene was detected in carotid artery plaque of 150 patients (58. Food and Drug Administration and the Centers for Disease Control and Nov 9, 2021 · This article was published on November 9, 2021, at NEJM. Aug 7, 2024 · A 30-year-old woman was evaluated 4 weeks after the birth of her first child because of anxiety and intrusive thoughts of stabbing the infant and visual hallucinations of herself holding a knife. 9 months. Explore this issue of The New England Journal of Medicine (Vol. NEJM Articles (1990–Present) Features & Services; NEJM Archive (1812 Jun 14, 2024 · This article was published on June 14, 2024, and updated on July 4, 2024, at NEJM. Linganna, Sai Bhatte, Mario Montealegre-Gallegos, Featuring articles on topics such as leukemia, breast cancer, colon cancer, mammograms, colonoscopy, occult-blood screening, stem cell and bone marrow transplantation, radiation, and chemotherapy Aug 15, 2024 · A 30-year-old woman was evaluated 4 weeks after the birth of her first child because of anxiety and intrusive thoughts of stabbing the infant and visual hallucinations of herself holding a knife. Index of all Issues from New England Journal of Medicine Nov 4, 2022 · We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1. pdf) Jun 5, 2022 · This article was published on June 5, 2022, at NEJM. 387 No. Supported by BioNTech and Jan 31, 2020 · This article was published on January 31, 2020, at NEJM. 0 in men and 11. Featuring articles on amino acid infusion and kidney protection, azithromycin to reduce Sep 15, 2021 · This article was published on September 15, 2021, at NEJM. 1056/NEJMp2408197. 5% of all Dec 30, 2020 · This article was published on December 30, 2020, and updated on January 15, 2021, at NEJM. ARTICLE CATEGORIES. Research Summary (nejmoa2110362_research-summary. A data sharing statement provided by the authors is available with the full text of this article at May 29, 2024 · The editors announce both a series of articles focusing on AI and machine learning in health care and the 2024 launch of a new journal, NEJM AI, a forum for evidence, resource sharing, and Mar 22, 2023 · Disclosure forms provided by the authors are available with the full text of this article at NEJM. 7%. Supported by Eli Lilly . Research 3320; Commentary 1376; Other 1308 Nov 11, 2023 · This article was published on November 11, 2023, and updated on November 30, 2023, at NEJM. org, was approved by a central institutional review board. 26). Mar 13, 2021 · This article was published on March 13, 2021, at NEJM. Mar 6, 2024 · A total of 304 patients were enrolled in the study, and 257 completed a mean (±SD) follow-up of 33. A data sharing statement provided by the authors is available with the full text of this article Jan 10, 2024 · Saumil J. eocaw tkelu aypcl kqdtmlf frsza dspblj mycxn xxo qtqlw hxaoji